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Psychiatric morbidities of female obesity before and after dieting: an Egyptian sample



The rate of occurrence of psychiatric morbidities like anxiety, depression, perceived stress, and the overall quality of life are very high among female patients with obesity; therefore, our study investigates such variables before and after weight loss in female patients on diet restriction; this can help obesity-multidisciplinary teams target these psychiatric correlates to reach a more satisfactory outcome.


Anxiety, depression, and perceived stress scores decreased significantly in parallel to the weight loss reported (p < 0.0001). Except for social functioning, all other domains of quality of life improved significantly after weight loss. Those with higher education level showed significantly lower stress, anxiety, and depression scores before weight loss compared to married and highly educated ones respectively. After weight loss, highly educated participants showed lower perceived stress and depression scores than those with middle education.


Anxiety, depression, and perceived stress factors are significantly decreased after weight reduction with an improved quality of life as well compared to their scores prior.


The World Health Organization has pointed to obesity (where the body mass index (BMI) is 30 kg/m2 or more) as one of the most prevented pandemics which have negative general medical and psychosocial consequences [1]. Low and middle income countries face a multifaceted challenge caused by obesity. Egypt has reported the occurrence of obesity among 31.4% of the adolescent population [2].

The literature explains that he hypothalamic–pituitary–adrenal axis dysregulation is responsible for appetite dysregulation and subsequent weight gain in patients with stressful life event [3, 4] as chronic stress is known to contribute to an increased risk of food addiction and obesity by enhancing the role of coping with compulsive behaviors like eating through the mesolimbic dopaminergic system and other brain regions involved in stress/motivation circuits synergistically potentiating the reward sensitivity, food preference, and craving for hyperpalatable foods [5].

Obesity is believed to be closely linked to mental health problems especially anxiety, depression [6], and stress [7]. There are other factors that contribute to contracting obesity like dire physical health, lack of physical exercise, deficient social support, low level of education, and financial burdens [8]. An Egyptian study found that 22.31% of mentally ill patients suffered from obesity, with the highest prevalence among patients with bipolar disorder (41.38%), (37.93%) among patients with depression, schizophrenia (10.34%), anxiety disorder (6.9%), and substance abuse disorder (3.45%) [9]. Another systematic review study revealed an evident bidirectional association between depression and obesity and vice versa especially among females, but considering anxiety and obesity it found a moderate link [10].

A study reported that obesity can cause adjustment depressive symptoms as patients with obesity were encountered to have a 55% increased risk of developing depression over time. And depression can lead to obesity whereas depressed persons were declared to have a 58% increased risk of becoming obese [11]. A systematic review study reflected on the improvement of depression, self-esteem, body image, and health-related quality of life especially (vitality) concurrently after engaging in dietary and behavioral weight loss programs [12]. Another study remarked on the high incidence rate of obesity among women with a noticeable relation between (anxiety and depression) and (weight change and obesity) among them [13]. Active weight-loss interventions have showed marked reduction in depressive symptoms in patients with obesity upon undergoing different modalities of weight loss programs like dietary counseling, diet-alone, supervised exercise sessions, pharmacotherapy, lifestyle modification programs with social support provided, and CBT which aimed at enhancing self-acceptance, reducing the perception of stigma, and fostering a sense of mastery and self-control [14].

Regarding management of obesity with psychiatric co-morbidities, psycho-education is very important about the risk factors and the importance of early detection and treatment, also liaison psychological and psychopharmacological treatment can facilitate weight loss and improve the clinical and functional outcome [15] therefore there is an emergent call to join patients in stress management techniques such as: diaphragmatic breathing, progressive muscle relaxation, guided visualization and to adopt healthy dietary habits in order to achieve successful weight reduction and to control anxiety and depression [16].

Therefore, our study aimed at elucidating the association of psychiatric morbidities and obesity in females, and hypothesized the reduction of anxiety, depression, perceived stress, and improvement of quality of life, after weight loss than prior.


Participants and procedure

This is an observational longitudinal study with convenient sampling carried out on 41 adult female patients at the obesity clinic at Menoufia University Hospitals, Egypt, from December 2015 till May 2016. There was no case drop out recorded. All participants were selected from female patients seeking weight loss programs for cosmetic purpose only, after explaining the purpose and procedure of the study, and obtaining written informed consent ensuring their confidentiality. Their age ranged from 18 to 55 years old (as young and middle ages were especially selected for their higher ability to follow weight reduction instructions especially exercising and because these two age categories are more subjected to emotional stress due to weight criticism, with BMI 30 kg/m2 or more). All subjects underwent dietary regimen set by professional nutritionists; based on their basal metabolic caloric requirement; and exercise on an escalating schedule; they were followed in the next visit as regards sticking to the nutritional rehabilitation program. No psychiatric intervention was given to the subjects. Patients having general medical causes of obesity like hypothyroidism, Cushing syndrome, or liver illnesses or taking medications that can cause weight gain like the hormonal contraceptive methods or cortisone were excluded from the sample. Also those with a known history of psychiatric disorder (like depression, binge eating, and bulimia nervosa) or undergoing any kind of psychiatric treatment or receiving psychotropic medications that can increase the body weight were excluded. Each interviewed patient was seen once again on a follow-up session 3 months later to complete the same assessment questionnaires. A 3-month duration between the 2 interviews was specifically chosen upon the standard first follow-up visit time set by nutritionist clinics to assess the anthropometric, dietary, and health effects of the nutritional interventional programs. After using the Central Limit Theorem that justifies the least sample size number to be 30 besides assessing the average number of patients attending the obesity clinic weekly, we estimated the total sample size to be 40. The study follows the Research Ethics Committee of the Faculty of Medicine, Menoufia University, Egypt.


A predesigned sheet on demographic data including age, educational level (basic education: pre-primary, primary, and preparatory level, middle education (general, vocational/technical, and the dual-system vocational levels), and high education (University education level)), marital status and BMI (that is measured before and after weight loss).

Hospital Anxiety and Depression Scale (HADS) [17]. Depressive and anxiety symptoms were assessed by the Arabic translated version of The Hospital Anxiety and Depression Scale. This self-assessment scale covers both anxiety and depression dimensions containing 14 items: 7 items referring to anxiety and 7 to depression, with a cut-off point of 8 for anxiety and 9 for depression. Each item’s score ranges from 0-3 so the person can score between 0 and 21 for either anxiety or depression. All items refer exclusively to the severity of the emotional state only without including the somatic symptoms. Answering the scale takes 2-5 min.

The Perceived Stress Scale-10 (PSS-10) [18]. We did not use the Arabic translated version. It consists of 10 items that inquire the degree to which respondents appraise their current life situation through the past month being stressful, unpredictable, and uncontrollable by responding on a 5-point Likert scale (0 = never, 1 = almost never, 2 = sometimes, 3 = fairly often, 4 = very often). Higher scores refer to higher perceived stress. The scale takes 5-10 min to be completed.

Short-Form 36 Health Survey (SF-36). Health-related quality of life (HEQoL) was assessed by applying the Arabic version of the Short-Form 36 Health Survey (SF-36) [19]. The scale is designed to measure the quality of life as a reflection of the patient’s health status, provided health care services outcome, and to assess disease burden. It is composed of 36 questions that evaluate the following domains: physical functioning (the ability to take care of oneself and to perform routine daily activities); role limitations caused by physical health problems (the impact of physical health in performing activities); bodily pain (level of pain experienced while performing routine daily activities); general health perceptions (how the individual perceives his/her health); vitality (energy and fatigue); social functioning (impact of physical conditions on his/her social life); role limitations caused by emotional problems (the extent to which emotional problems interfere in routine daily activities); and the mental health domain (effect of mood on his/her life). The scores range from 0 (most affected) to 100 (not affected). The scale requires 10 min to be filled.

Study procedure

Interview 1: Patients had a primary interview that took around 30 min where they answered items of the predesigned sheet and the 3 assessment scales and BMI was measured.

Interview 2: Patients were contacted via phone to arrange a meeting with the researcher on their 3 month follow-up visit at the obesity clinic where the predesigned sheet and the same 3 scales were answered and the BMI was measured as well.

Statistical analysis

All data were recorded in a statistical package on a compatible computer. Results were tabulated and statistically analyzed by the Statistical Package for the Social Sciences (SPSS) version 20 [20]. Wilcoxon signed-rank test was used to compare the patients’ results before and after weight loss. Mann Whitney test was used to compare the results of highly educated patients with those with middle education and single to married patients, before and after weight loss. Spearman correlation was used to detect correlations; whether positive or negative; between different variables. Statistically significant findings were determined by a two tailed P value < 0.05.


Demographics data

The present study included 41 females with age ranging between 19 and 48, with mean age 29.73 ± 7.7; considering the marital status, 17 (41.5%) were single and 24 participants (48.5%) were married. Regarding the educational level, 21 (51.2%) of the participants completed their high education (University education), while 20 (48.8%) completed middle education (Technical education). At the start of the study participants’ BMI ranged between 29.76 and 56.14, with a mean of 36.3 ± 6.4, which decreased 3 months later to a range of 24.69 to 43.37 with a mean of 29.9 ± 4.7.

Anxiety and depression scores before and after weight loss

There was a statistically significant difference in anxiety symptom scores before and after weight loss (P = 0.0001) where scores ranging between 2 and 21 decreased from a mean of 12.1 ± 5.5 (before weight loss) to a range of 1 to 15 with a mean of 8.1 ± 2.9 (after weight loss).

There was also a statistically significant difference in depression scores before and after weight loss (P = 0.0001) where scores ranging between 0 and 21 decreased from a mean of 10.2 ± 5.5 (before weight loss) to a range of 0 to 15 with a mean of 7 ± 3.5 (after weight loss) (Table 1).

Table 1 Anxiety, depression, and perceived stress scores before and after weight loss

Abnormal levels of anxiety and depression symptoms: HADS 11-21 scores were found in 24 (58.5%) and 19 females (46.3%) respectively before weight loss, while after weight loss only 6 females (14.6%) showed abnormal HADS scores.

Perceived stress scores before and after weight loss

The study findings reported high score levels in the PSS-10 scale with obesity (with a range of 11 to 40 and a mean of 24.62 ± 6.47) that significantly decreased (to a range of 11 to 31 and a mean of 20.05 ± 4.09) after the 3 month weight loss trial (Table 1).

Quality of life scores before and after weight loss

Except for pain, social functioning, and physical functioning, and all other domains scores were less than fifty before the weight-loss trial. After weight loss, all the eight SF-36 Health Survey domain scores increased to reach higher than fifty (Table 2).

Table 2 Comparison between SF-36 quality of life scores before and after weight loss

No correlations were found between BMI and psychiatric morbidities (anxiety symptom, depression symptom, and perceived stress scores). Only an inverse correlation was found between body weight and “role limitations caused by emotional problems” QoL domain (rho −0.345, p < 0.027), yet this correlation was not found after weight loss.

Obesity-related psychiatric correlates in relation to educational level

Regarding education, participants with high education rank showed significantly lower BMI than subjects with middle education level before and after the weight-loss trial.

Also, participants with high education also showed significantly lower perceived stress, anxiety, and depression scores before weight loss when compared with those with middle education, with a statistically significant difference between both groups regarding perceived stress factor (P = 0.005) (Table 3). And after weight loss trial, they also showed significantly lower stress, depression scores, and more improvement in the “general health perception” and “role limitations caused by emotional problems” QoL domain scores than participants with middle education, with statistically significant difference between both groups regarding perceived stress factor (P = 0.004) (Table 4).

Table 3 Education level in relation to anxiety, depression, and perceived stress before weight reduction
Table 4 Education level in relation to anxiety, depression, and perceived stress after weight reduction

Obesity and its psychiatric correlates in relation to marital status

No statistically significant differences were found between single and married participants regarding BMI before and after the weight loss trial. Married participants showed higher anxiety and depression scores (p < 0.001) and lower scores on physical functioning and vitality domains of the QoL scale before weight loss in comparison to single participants. All these differences between the two groups were not found after the weight-loss trial.


Obesity in relation to depressive and anxiety symptoms

Our study findings showed abnormal levels of anxiety and depressive symptoms in 58.5% and 46.3% of patients respectively with obesity (before engaging in the weight loss programs). The strong link between anxiety and obesity can be explained by the negative impact of obesity on the patient’s self-esteem with the sense of being socially ridiculed [21] especially with poor sociocultural support and awareness about body dissatisfaction and body image, and this can lead to various picture of anxiety-like panic attacks and social phobia. While the evident link between depression and obesity can be explained by the restricted daily routine like low physical activity, relational problems, marital problems, emotional, and physical abuse vulnerability, besides the obesity-related physical complications burden causing frustration and more of chronic stress. Also, symptoms of anxiety are not only reported to increase the appetite but to stimulate craving for high-sugar and high-fat foods as well [22,23,24]. Likely many studies pointed out the strong association between obesity and anxiety and depressive symptoms [25,26,27,28,29].

In agreement with our results concerning the significant comorbidity of anxiety symptoms and obesity, an Egyptian study screening 93 Arab females at the obesity clinic demonstrated that the severity of anxiety symptoms was positively correlated with the subjects’ age, maximum weight, BMI, duration of obesity (in years), and duration since last pregnancy [30]. Another review study revealed high anxiety levels in patients with obesity and higher in those with morbid obesity, which can be explained by the susceptibility of patients with obesity to public and private discrimination, being deprived of many life opportunities, contracting poor socioeconomic status, having fragile social support, facing continuous societal pressure to control their weight problem, frustration after repeated failed attempts of dieting, and resisting preoccupation by eating, plus the fear of having physical complications associated with obesity [31].

And regarding the significant morbidity of depression with obesity, various studies found a close association between obesity and depression [32,33,34,35,36,37] due to the positive relation between depression and emotional eating [38] as well as the associated poor body image, lack of competence, interpersonal problems, and internalization of weight bias with obesity [32].

Furthermore, a study found that atypical depression is associated with chronic psycho-immuno-neuro-endocrinal dysfunction due to inflammatory, leptin-ghrelin, neuroendocrinal, and gut microbiome systems influenced by chronic image-associated psychological stress and sensitivity to rejection especially in young female patients that can lead to behavioral dysregulation in the form of hyperphagia, lethargy, and hypersomnia [39].

The current study found that anxiety and depression scores decreased after weight reduction and this can be explained by the strong bidirectional relation between anxiety and depression causing emotional eating and obesity, this is supported by the findings of Bulik and colleagues in 2002 [40] who found that compared to obese women without binge eating, obese women with binge eating reported a higher rate of occurrence of psychiatric problems like neuroticism, depression, anxiety disorders (panic disorder, phobia, obsessive-compulsive traits), insomnia, psychomotor agitation or retardation, and suffering from major general medical diseases.

Another study showed that greater improvements in depression were associated with better weight loss outcomes in women in rural parts of states in the USA [41]. In addition, a 5 session aerobic exercise protocol per week during 12 months period and nutritional rehabilitation proved to give better depression level reduction compared to a control group (P ≤ 0.05) with the physical activity group showing more improvement than the diet group (P = 0.001, P = 0.006) [42]. On the other hand, dietary interventions for weight loss had a significant impact on reducing the magnitude of obesity, depression, and anxiety symptoms [43] because of their anti-inflammatory, neuroprotective, and prebiotic properties [44, 45].

Obesity in relation to perceived stress

Our study showed a high perceived stress associated with obesity that was markedly reduced post-weight control, and this explains the effect of obesity on the patient causing chronic stress due to the struggling with poor self-image, lack of self-esteem, continuous criticism, social alienation, leading to more of food craving as a way of coping and stress relief and being more trapped in the obesity loop. And such stress is associated with neuro-endocrinal effects on altering glucose metabolism, insulin sensitivity, cortisol level, and other hormones related to energy homeostasis which can concomitantly affect the dopaminergic reward center activity for increased consumption of highly palatable foods [46].

Agreeing with our results, a study found that 47.1% of patients with obesity referred to hospital settings had pathological General Health Questionnaire scores [47]. Nevertheless, a positive correlation was found between perceived stress and uncontrolled eating and emotional eating behaviors [48] as well as increased body mass index [48,49,50,51].

Obesity in relation to quality of life

The current study findings revealed an inverse correlation between obesity and “role limitations caused by emotional problems” QoL domain with an improvement in the majority of the QoL domains after weight reduction.

Agreeing with our results, a study found that female patients suffering from obesity had an inverse correlation between obesity and both the physical and the mental components of the HRQoL scale, also physical component scores of the HRQoL (physical functioning, role physical, bodily pain, vitality, general health conception) were associated with higher BMI grades, higher educational achievement, and more psychiatric comorbidities [52]. Moreover, a study showed that obesity had an impact on 20.3% of the general health quality of life of females and 17.8% of their physical functioning [53].

Also, more of an inverse correlation between obesity and health-related quality of life was demonstrated in other studies [54,55,56]. Many patients were motivated to seek weight-loss treatment due to their significant difficulties with physical and occupational functioning [57, 58], as weight loss was reported to be typically associated with improvements in psychosocial status and functioning [59].

Educational level in relation to obesity and its psychiatric comorbidities

Our study revealed that high education is accompanied by lower anxiety, depression, and perceived stress scores before and after weight reduction compared to female patients with middle education level with statistically significant difference regarding perceived stress factor (P = 0.004, 0.005, before and after weight reduction respectively). This can be explained by the notion that reaching high education facilitates better coping with stress, and this is supported by the findings of a study revealing that higher perceived stress was associated with greater intake of energy from fat, high-fat snacks, and fast-food items as well as lower intake of energy from carbohydrates [60]. Similarly, a study reflected that women with university degrees had a 2.1 kg/m2 lower BMI compared to that of women with lower education levels because of being more preoccupied by body image issues and leading a higher energy expenditure lifestyle [61]. Also, the prevalence of depression was found to be associated with lower educational level [33, 62], lower economic status, and metabolic syndrome than the control group [62].


Female patients with obesity (especially ones with higher education level) recorded lower anxiety, depression, and perceived stress scores as well as higher quality of life scores after weight reduction than before joining weight loss programs. These findings can help obesity clinic team implement updated systems of screening for psychiatric comorbidities with obesity (especially stress, anxiety, and depression) and monitoring them during weight reduction procedures. In addition, it is necessary to assess the severity of such morbidities in order to determine the most suitable plan of management for each patient like cognitive behavior therapy, interpersonal psychotherapy, improving one’s coping and stress management strategies, and using pharmacotherapy if needed.

Strength and limitations

The study did not highlight the causes of obesity in the patients, and whether they have underlying binge eating disorder or not as it can contribute to and be related to the presence of anxiety, depression, and stress in the patients. Also, the small sample size makes it difficult to give representative findings for all the population.

Availability of data and materials

Data will not be shared, as wished by the participants in the study.



Body mass index


Hospital Anxiety and Depression Scale


The Perceived Stress Scale-10


Short-Form 36 Health Survey


Health-related quality of life


Statistical Package for the Social Sciences


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We are expressing our cordial gratitude to the appreciated effort and time given by all patients in the study.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations



A.S.S: offering the research idea and sampling plan, contribution in paper writing, methodology. S.A.S: recruiting and interviewing the patients, applying the questionnaires and sample collection. D.A.M.: contribution in paper writing and revising the references, paper submission. All authors have read and approved the manuscript.

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Correspondence to Dalia Abdel Moneim Mahmoud.

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Ethics approval and consent to participate

Subjects were enrolled in the study after explaining the purpose and procedure of the study and obtaining a written informed consent ensuring their confidentiality. The study follows the Research Ethics Committee of the Faculty of Medicine, Menoufia University, Egypt. The reference number of the Committee approval is not available.

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Not applicable.

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The authors have no competing interests to report.

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This work was conducted at Obesity Clinic at Menoufia University Hospitals, Egypt.

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Shalaby, A.S., Sadik, S.A.M. & Mahmoud, D.A.M. Psychiatric morbidities of female obesity before and after dieting: an Egyptian sample. Middle East Curr Psychiatry 27, 62 (2020).

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