Efficacy, safety, and tolerability of serotonin-norepinephrine reuptake inhibitors in controlling ADHD symptoms: a systematic review and meta-analysis

Middle East Current Psychiatry

Table 3 Meta-analysis results of the efficacy of SNRIs in ADHD

Measure	Number of studies	Pooled SMD (95% CI)	Heterogeneity assessment
Measure	Number of studies	Pooled SMD (95% CI)	I Squared%	Model	P value
SNRIs	10	− 2.20 [− 3.00, − 1.40]	86.93	Random	< 0.001
Venlafaxine (overall)	7	− 1.86 [− 2.69, − 1.02]	86.20	Random	< 0.001
Venlafaxine (Hyperactivity-Impulsivity)	4	− 1.00 [− 1.35, − 0.65]	86.45	Fixed	< 0.001
Venlafaxine (Inattention)	3	− 1.52 [− 1.92, − 1.12]	90.32	Fixed	< 0.001
Duloxetine	3	− 2.65 [− 3.35, − 1.96]	79.34	Fixed	< 0.001