Cell therapies for autism spectrum disorder: a systematic review of clinical applications

Middle East Current Psychiatry

Table 4 Summary of the outcome of studies conducted with cord blood TNC

	Chez et al. [15]	Dawson et al. [20]	Dawson et al. [21]	Simhal et al. [81]
CGI-I	No change	Improved significantly	Improved^a	No change
CGI-S	No change	Improved significantly	No change	-
EOWPVT	No change	Improved significantly	No change	No change
ROWPVT	No change	Improved significantly	-	-
VABS	No change	Improved significantly	Improved	No change
PDDBI	-	-	No change	No change
Daily skills, learning capacity	No change	Improved significantly	-	No change
Social interaction	No change	Improved significantly	No change	No change
Adaptive behavior	No change	Improved significantly	-	No change
Verbal cognitive ability	No change	Improved significantly	-	No change
Brain network reconfiguration	-	-	Significant change^b	Significant change^b
Major adverse events	None	None	None	-

^aCGI rating improvement was observed when only participants with NVIQ≥70 were compared with the placebo group
^bSignificant change was observed when statistical analyses were performed by grouping patients according to their nonverbal IQ