Table 2 Mean value of psychiatric symptoms and cognitive performance at different time points in the study

HADS scale

Anxiety

7.99 ± 4.2

6.55 ± 3.5

5.92 ± 2.8

8.453

0.001*

0.006*

0.238

0.001*

Depression

7.3 ± 3.3

6.5 ± 3.2

5.9 ± 3.1

4.699

0.017*

0.208

0.430

0.012*

25.70 ± 1.46

25.55 ± 1.81

25.74 ± 1.613

1.162

0.316

0.238

0.219

0.774

WAIS-IV subtests

Digit symbol test

38.78 ± 13.71

33.44 ± 13.6

40.46 ± 14.02

12.143

0.001*

0.006*

0.001*

0.391

Forward span

7.67 ± 2.29

6.99 ± 2.33

7.83 ± 2.57

4.51

0.026*

0.014*

0.006*

0.574

Backward Span

5.43 ± 2.26

4.71 ± 2.21

5.81 ± 2.38

5.621

0.007*

0.024*

0.003*

0.248

Block design test

26.11 ± 8.707

21.58 ± 6.4

28.18 ± 9.171

11.32

0.001*

0.001*

0.001*

0.104

Arithmetic test

7.98 ± 1.583

7.24 ± 1.585

7.99 ± 1.678

5.687

0.012*

0.006*

0.005*

0.875