N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile

Middle East Current Psychiatry

Table 3 Statistical correlation of anti-NMDAR antibody with parameters obtained from clinical rating scales in the patient group of the study

Parameter		NMDA		Test of significance
		Negative	Positive	Test of significance
		Mean ± SD	Mean ± SD	Value	p-value	Sig.
		N (%)	N (%)	Value	p-value	Sig.
ADOS level of Autism related symptoms	Mild	4 (6.25%)	3 (13.04%)	X² = 3.786	0.151^(C)	NS
	Moderate	29 (45.31%)	14 (60.87%)
	High	31 (48.44%)	6 (26.09%)
Probability to diagnose ASD in GARS		87 (65–89)	35 (19–84)	*U =* 414.5	0.002^(M)	S
Stereotyped behavior most affected	Sensory	30 (46.88%)	12 (52.17%)	X²= 4.621	0.099^(C)	NS
	Verbal	27 (42.19%)	5 (21.74%)
	Motor	7 (10.94%)	6 (26.09%)
Stereotyped behavior degree	Low	32 (50%)	12 (52.17%)		< 0.001^(F)	S
	Below average	32 (50%)	5 (21.74%)
	Average	0 (0%)	6 (26.09%)
Vineland’s domain most affected	Communication	21 (32.81%)	8 (34.78%)		0.474^(F)	NS
	Daily life	0 (0%)	0 (0%)
	Social	19 (29.69%)	7 (30.43%)
	Motor	0 (0%)	1 (4.35%)
	Communication + Social	24 (37.5%)	7 (30.43%)
Total calibrated score of Vinland Adaptive Behavior Scale		31 (26–31)	45 (39–51)	*U =* 247.0	< 0.001^(M)	S
Age coefficient		0.16 (0.13–0.27)	0.28 (0.2–0.4)	*U =* 365.5	< 0.001^(M)	S

SD Standard deviation, N Number, S Significant, NS Not significant, ^(T)Student’s t-test of significance (t = Student’s t-test value). ^(C)Chi-square test of significance (X² = chi-square test value). ^(F)Monte-Carlo Fisher’s exact test of significance. ^(M)Mann-Whitney test of significance (U = Mann-Whitney’s test value)