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Table 3 Statistical correlation of anti-NMDAR antibody with parameters obtained from clinical rating scales in the patient group of the study

From: N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile

Parameter

NMDA

Test of significance

Negative

Positive

Mean ± SD

Mean ± SD

Value

p-value

Sig.

N (%)

N (%)

ADOS level of Autism related symptoms

Mild

4 (6.25%)

3 (13.04%)

X2 = 3.786

0.151(C)

NS

Moderate

29 (45.31%)

14 (60.87%)

High

31 (48.44%)

6 (26.09%)

Probability to diagnose ASD in GARS

87 (65–89)

35 (19–84)

U = 414.5

0.002(M)

S

Stereotyped behavior most affected

Sensory

30 (46.88%)

12 (52.17%)

X2= 4.621

0.099(C)

NS

Verbal

27 (42.19%)

5 (21.74%)

Motor

7 (10.94%)

6 (26.09%)

Stereotyped behavior degree

Low

32 (50%)

12 (52.17%)

 

< 0.001(F)

S

Below average

32 (50%)

5 (21.74%)

Average

0 (0%)

6 (26.09%)

Vineland’s domain most affected

Communication

21 (32.81%)

8 (34.78%)

 

0.474(F)

NS

Daily life

0 (0%)

0 (0%)

Social

19 (29.69%)

7 (30.43%)

Motor

0 (0%)

1 (4.35%)

Communication + Social

24 (37.5%)

7 (30.43%)

Total calibrated score of Vinland Adaptive Behavior Scale

31 (26–31)

45 (39–51)

U = 247.0

< 0.001(M)

S

Age coefficient

0.16 (0.13–0.27)

0.28 (0.2–0.4)

U = 365.5

< 0.001(M)

S

  1. SD Standard deviation, N Number, S Significant, NS Not significant, (T)Student’s t-test of significance (t = Student’s t-test value). (C)Chi-square test of significance (X2 = chi-square test value). (F)Monte-Carlo Fisher’s exact test of significance. (M)Mann-Whitney test of significance (U = Mann-Whitney’s test value)