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Table 2 Comparison of efficacious laxative regimens [38]

From: Management of constipation in patients with schizophrenia—a case study and review of literature

  MOA Benefit
Lactulose Converts NH3 to NH4+ Increases stool frequency by 40%
Polyethylene glycol (MiraLAX) Osmotic agent, causes water retention in stool thereby increasing stool frequency Most effective osmotic agent (especially without electrolytes), palatability increases patient compliance, decreases incidence of fecal impaction and increased stool frequency by 60%
Docusate sodium Reduces surface tension of oil-water interface of stool resulting in enhanced incorporation of water and fat Overall baseline mean of 3.4 bowel movements
Psyllium Soluble fiber that absorbs water in intestine that promotes peristalsis and reduces transit time Better at increasing stool water content and total stool output in comparison to docusate
Senna Induces peristaltic activity via enteric nerve stimulation Fast acting