Table 2 Comparison of efficacious laxative regimens [38]
From: Management of constipation in patients with schizophrenia—a case study and review of literature
MOA | Benefit | |
|---|---|---|
Lactulose | Converts NH3 to NH4+ | Increases stool frequency by 40% |
Polyethylene glycol (MiraLAX) | Osmotic agent, causes water retention in stool thereby increasing stool frequency | Most effective osmotic agent (especially without electrolytes), palatability increases patient compliance, decreases incidence of fecal impaction and increased stool frequency by 60% |
Docusate sodium | Reduces surface tension of oil-water interface of stool resulting in enhanced incorporation of water and fat | Overall baseline mean of 3.4 bowel movements |
Psyllium | Soluble fiber that absorbs water in intestine that promotes peristalsis and reduces transit time | Better at increasing stool water content and total stool output in comparison to docusate |
Senna | Induces peristaltic activity via enteric nerve stimulation | Fast acting |