Adjunctive repetitive transcranial magnetic stimulation therapy’s effectiveness in treating a sample of patients with major depressive disorder refractory to first-line drug treatment

Middle East Current Psychiatry

Table 2 Clinical outcomes in the intervention and sham groups

Variable		Sham rTMS (n = 30)	Active rTMS (n = 30)	ANOVA^a		ANOVA^b
Variable		Sham rTMS (n = 30)	Active rTMS (n = 30)	F	p	F	p
HDRS	Baseline	20.03 ± 7.40	19.66 ± 6.70	10.87	0.001	5.98	0.01
	Week 2nd	19.36 ± 6.86	12.50 ± 6.96
	Week 4th	18.53 ± 7.10	11.23 ± 6.95
GGI-S	Baseline	4 ± 0.83	3.80 ± 0.76	20.36	p < .001	9.95	p = 002
	Week 2nd	3.86 ± 0.89	3.30 ± 1.13
	Week 4th	3.83 ± 0.98	2.86 ± 1.27
B-IPQ	Baseline	56.60 ± 11.26	55.23 ± 12.90	15.75	p < .001	3.99	0.03
	Week 2nd	55 ± 11.25	48 ± 14.22
	Week 4th	53.13 ± 14.24	46.66 ± 12.93

^aRepeated-measures analysis of variance (ANOVA), consider the effect of time
^bRepeated-measures analysis of variance (ANOVA), interaction of group and time (active vs. sham)
Brief IPQ, Brief Illness Perception Questionnaire; CGI-S, the Clinical Global Impression-Severity scale